The US will withdraw all diplomatic staff from Venezuela this week due to the “deteriorating situation” there, the state department has announced.
In a tweet, Secretary of State Mike Pompeo said having staff in Caracas had “become a constraint on US policy”.
The US ordered all non-essential staff to leave Venezuela in January amid an ongoing diplomatic crisis.
Widespread power cuts and a worsening humanitarian crisis have sparked mass protests.
The decision to vacate the embassy came late on Monday and followed critical comments Mr Pompeo made to reporters about Venezuelan President Nicolás Maduro.
Relations between the two countries have plummeted in recent months.